Моделирование молекулярных механизмов фагоцитоза нейтрофилов на принципах электрохимического окисления в абдоминальной хирургии

In in vitro experiments examined the redox potential of the inorganic and organic media, which were exposed to different concentrations of sodium hypochlorite. In the study, adding sodium hypochlorite followed by an increase of redox potential of the studied media, that indicates an increase in resistance of the body relative to the saprophytic anaerobes. In the study of the chemiluminescence of neutrophils after exposure to different concentrations of sodium hypochlorite, it was noted that the 0,03% solution causes the most intense flash of chemiluminescence, which at 18 minutes reaches its maximum value, at the time, as using 0,06% solution chemiluminescence is fading. The results indicate that stimulation of neutrophils with low concentrations of sodium hypochlorite promotes the maximum release of reactive oxygen species, triggering peroxidation of biological membranes, which determines the primary mechanism of phagocytosis of bacterial cells.