Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma

Background: Glioma, most common primary malignant brain tumor in adults, is highly aggressive and associatedwith a poor prognosis. Evaluate the association of polymorphisms related of to the cell cycle, integrity and DNA repairwith gliomas, as well as lifestyle habits, comorbidities, survival and response to treatment. Methods: Were studied303 individuals distributed into: Study Group - 100 patients with gliomas, regardless of the degree of malignancy, andControl Group - 203 individuals without clinical signs of the disease. These polymorphisms were genotyped by TaqMan®SNP Genotyping Assay. Significance level was set at 5%. Results: Smoking, alcohol consumption, systemic arterialhypertension (SAH) and diabetes mellitus (DM) prevailed in patients, compared to controls (P=0.0088, P=0.0001,P=0.0001, P=0.0011, respectively). In the logistic regression analysis, alcohol consumption and SAH were identifiedas independent risk factors for gliomas (P=0.0001, P=0.0027, respectively). Patients with low-grade gliomas showedsurvival in one year (92.0±6.8%), compared to patients with high-grade gliomas (24.0±5.3; P=0.011). Conclusion:Polymorphisms involved in cell cycle, telomere protection and stability and DNA repair are not associated with gliomas.On the other hand, alcohol consumption and SAH stand out as independent risk factors for the disease. Low-gradegliomas, response to treatment and the combination of chemotherapy with Temozolomide and radiation therapy showincreased survival of patients.