Increased cancer risk in a large population-based cohort of patients with primary biliary cirrhosis: follow-up for up to 36 years

Background and aims The natural history of primary biliary cirrhosis (PBC) has so far mainly been studied in tertiary referral centres. The aim of the present investigation was to describe the natural history of PBC in a large population-based cohort in order to identify risk factors for development of malignancies and disease progression.