Development and in-vitro evaluation of sustained release matrix tablets ofAcelofenac using different grade of Methocel K100m Cr polymer

In the present study, an attempt has been made to evaluate the effect of hydrophilic polymers on the release profile of drug from matrix system. Acelofenac, a non-steroidal anti-inflammatory drugs agent, was used as a model drug to evaluate its release characteristics from different matrices. Matrix tablets of Acelofenac were prepared by direct compression process using Methocel K100m CR polymer. Release kinetics of Acelofenac from these sustained release matrices in distilled water using USP paddle method with sinker for 8 hours was studied. Statistically significant differences were found among the drug release profile from different formulations. Higher polymer content (70%) in the matrix decreased the rate of the drug due to increased tortuosity and decreased porosity. At lower polymeric level (30%), the rate of drug release was elevated. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer equations. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physicochemical properties of the drug.