A Lower Level of Entropy in Circadian Rhythm of the Sinus R‐R Intervals Suggests a Prevalence of the Cardiac Sympathetic Regulation in Early Physiological Pregnancy

The study estimates the unpredictable disorder (chaos) within the 24 h pattern of sinus R‐R intervals (SRRI) in clinically healthy pregnant women (CHPW) and clinically healthy non‐pregnant women (CHNPW), in order to evaluate the early gestational changes in neurovegetative cardiac pacing. SRRI were provided by the 24‐h Holter ECG of 10 CHPW and 10 CHNPW. SRRI were investigated by descriptive conventional statistics by means of the Time and Frequency Domain Analysis, and subsequently, in their chaotic component by means of entropy analysis. Both the SRRI and entropy were tested via the Cosinor method to better decipher whether or not the periodic disorder in heart rate variability is modified in pregnancy as a result of a gestational tonic resetting of the cardiac sympatho‐vagal regulation. Cosinor analysis documented that the circadian rhythm of both the SRRI and entropy were preserved in CHNPW and CHPW. However, the circadian rhythm of SRRI and entropy in CHPW exhibited a significantly decreased 24 h mea...