Drug susceptibility of Trichosporon beigelii isolated from urine and clinical features of their hosts

: We investigated of Trichosporon beigelii by a surveillance study for two years in the Tokyo Metropolitan Police Hospital. T. beigelii was frequently found in the urine in aged patients with indwelled urethral catheter and in serious stage patients associated with malignancy. T. beigelii was in all cases isolated from the samples of patients in a hospital stay over 5 days. Minimum inhibitory concentrations (MICs) of anti-fungal agents against T. beigelii were determined by agar-dilution method. Fluconazole resistant strains of T. beigelii were found by this method. Microscopic examination revealed phagocyted T. beigelii in multinucleated neutrophils in some cases. In conclusion, T. beigelii might be suggested a causative organism of opportunistic infection in urinary diseases.