Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda

Masatomo Kawakubo,Hitomi Komura,Yukinobu Goso,Motohiro Okumura,Yoshiko Sato,Chifumi Fujii,Masaki Miyashita,Nobuhiko Arisaka,Satoru Harumiya,Kazuhiro Yamanoi,Shigenori Yamada,Shigeru Kakuta,Hiroto Kawashima,Michiko N. Fukuda,Minoru Fukuda,Jun Nakayama

Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda

2019

Masatomo Kawakubo
Hitomi Komura
Yukinobu Goso
Motohiro Okumura
Yoshiko Sato
Chifumi Fujii
Masaki Miyashita
Nobuhiko Arisaka
Satoru Harumiya
Kazuhiro Yamanoi
Shigenori Yamada
Shigeru Kakuta
Hiroto Kawashima
Michiko N. Fukuda
Minoru Fukuda
Jun Nakayama

Gastric adenocarcinoma cells secrete sulfomucins, but their role in gastric tumorigenesis remains unclear. To address that question, we generated A4gnt/Chst4 double-knockout (DKO) mice by crossing ...

Keywords:

Molecular biology
Pathology
Knockout mouse
Biology
Gastritis cystica profunda
Secretion
gastric adenocarcinoma
Cancer research
Carcinogenesis
o glycan

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