Rapid Assembly of the 1-Azabicyclo[3.1.0]hexane Skeleton of Ficellomycin

The 1-azabicyclo[3.1.0]hexane core of ficellomycin can be assembled in a concise manner by way of a double cyclisation reaction involving in situ generation of an NH aziridine and further intramolecular conjugate additiononto a dehydroamino ester.