Urinary enzyme changes in children undergoing cineangiographic evaluation using iopromid

Nephropathy due to radiocontrast media presents with a wide spectrum of changes from reversible renal dysfunction to oliguria requiring dialysis. Nineteen patients (mean age 4.5±3.7 years) were included. Mean±SD values of the variables obtained before and 48 hours after angiography were the following: plasma creatinine: 0.6±0.10 and 0.6±0.16 mg/dl; endogenous creatinine clearance: 76.1±17.0 and 80.9±19.3 ml/min/1.73 m2; plasma osmolality: 279±23 and 298±39 mOsm/kg H2O; urine osmolality: 429±225 and 459±196 mOsm/kg H2O; fractional sodium excretion: 2.1±1.3% and 2.4±1.3%; plasma uric acid: 3.9±1.3 and 3.4±1.0 mg/dl; urinary AST/creatinine: 5.2±4.8 and 4.2±2.6 mU/mg; ALT/creatinine: 16.8±12.4 and 15.3±12.6 mU/mg; LDH/creatinine: 52.0±39.6 and 42.3±31.5 mU/mg; NAG/creatinine: 20.1±2.8 and 16.8±2.3 mU/mg, respectively. The changes in renal function parameters and urinary enzyme levels were insignificant statistically (p>0.05). In conclusion, iopromid injection at maximum doses of 5 ml/kg does not result in injury to the tubular epithelium leading to increased urinary enzyme levels.