3-hydroxy-3-cyclobutene-1,2-dione: Application of novel carboxylic acid bioisostere to an in-vivo active non-tetrazole angiotensin-II antagonist

Richard Soll,W.A. Kinney,John Primeau,Lloyd Michael Garrick,R.J. McCaully,Thomas J. Colatsky,George Oshiro,C.H. Park,D. Hartupee,V. White,John D. McCallum,A. Russo,J. Dinish,Alexandra Wojdan

3-hydroxy-3-cyclobutene-1,2-dione: Application of novel carboxylic acid bioisostere to an in-vivo active non-tetrazole angiotensin-II antagonist

1993

Richard Soll
W.A. Kinney
John Primeau
Lloyd Michael Garrick
R.J. McCaully
Thomas J. Colatsky
George Oshiro
C.H. Park
D. Hartupee
V. White
John D. McCallum
A. Russo
J. Dinish
Alexandra Wojdan

Abstract Application of the novel carboxylic acid bioisostere 3-hydroxy-3-cyclobutene-1,2-dione to the design of a potent, non-peptidic, non-tetrazole angiotensin II antagonist 4 is described.

Keywords:

Antagonist
Angiotensin II
Stereochemistry
Cyclobutene
In vivo
Carboxylic acid
Tetrazole
Organic chemistry
Bioisostere
Chemistry
angiotensin ii antagonist

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