Assembly of functionally integrated human forebrain spheroids

Fikri Birey,Jimena Andersen,Christopher D. Makinson,Saiful Islam,Wu Wei,Nina Huber,H. Christina Fan,Kimberly R. Cordes Metzler,Georgia Panagiotakos,Nicholas Thom,Nancy A. ORourke,Lars M. Steinmetz,Jonathan A. Bernstein,Joachim Hallmayer,John R. Huguenard,Sergiu P. Paşca

Assembly of functionally integrated human forebrain spheroids

2017

Fikri Birey
Jimena Andersen
Christopher D. Makinson
Saiful Islam
Wu Wei
Nina Huber
H. Christina Fan
Kimberly R. Cordes Metzler
Georgia Panagiotakos
Nicholas Thom
Nancy A. ORourke
Lars M. Steinmetz
Jonathan A. Bernstein
Joachim Hallmayer
John R. Huguenard
Sergiu P. Paşca

Human pluripotent stem cells were used to develop dorsal and ventral forebrain 3D spheroids, which can be assembled to study interneuron migration and to derive a functionally integrated forebrain system with cortical interneurons and glutamatergic neurons.

Keywords:

Dorsum
Induced pluripotent stem cell
Neuroscience
Neural stem cell
Glutamatergic
Interneuron migration
Forebrain
Spheroid
Anatomy
Biology
Nervous system
Neural development
Neurogenesis
Human brain

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