Antiepileptic drugs in pregnancy and malformations

: The use of antiepileptic drugs in pregnancy may be responsible of minor or major developmental abnormalities at birth or in infancy. The severity of effects and heterogeneity of that abnormalities might be related to a special genetic background giving the fetus a predisposition for epilepsy and vulnerability to major or minor anomalies. The authors report the case of a pregnant woman self prescribing of a politherapy without medical control. She gave birth to a newborn with sever intrauterin retardation, various dysmorphic features and moderate psychomotor delayed.