Levels of Pro and Anti-inflammatory Citokynes and C-Reactive Protein in Patients with Chronic Periodontitis Submitted to Nonsurgical Periodontal Treatment

Aim: to compare the levels of IFN-γ, TGF-β and C-reactive protein (CRP) in healthy patients (HP) and chronicperiodontitis patients (CP) before and seven days after the last session of Non-Surgical Periodontal Treatment (NSPT).Materials and Methods: 40 subjects were divided into two groups: healthy (n= 20), and with chronic periodontitis(n = 20). Serum and gingival crevicular fluid (GCF) were collected from each patient and quantified for IFN-γ,TGF-β and CRP using the enzyme-linked immunosorbent assay (ELISA). Results: IFN-γ was found to be higher inthe GCF of the CP group before NSPT in relation to the HP group (p 0.05). Serum CRP levels did not showstatistical difference between CP and HP before or after NSPT. Conclusion: Therefore, our results demonstrated forthe first time that NSPT causes early exacerbation of the immune response at the local level represented by increasedlevels of IFN-γ and decreased levels of TGF-β in the gingival crevicular fluid after seven days of treatment.