Rapid and Non-Invasive Screening System for Early Detection of Diabetic Retinopathy via Auto Fluorescence of Falvin Proteins

Diabetic retinopathy is one of the most serious complications of diabetes, which is also one of the most important causes of blindness around the world. Autofluorescence of flavin protein in retinal pigment epithelial cells is considered as a marker of early tissue damage. This study was designed to image spontaneous fluorescence of falvin proteins in fundus macular center area. The average intensity of the fluorescence signal and the characteristics of the histogram distribution were obtained and the significant differences in the fluorescence signals between the diabetic and the normal people were also compared with statistical methods, and then a rapid and non-invasive screening method and equipment for early detection of diabetic retinopathy were developed.