Efectos PREVENTIVOS del policosanol y el aceite de pescado omega-3 sobre la isquemia cerebral global en Mongolian gerbils

Stroke is the third cause of death and the first of permanent adult disability. Pre-treatment with policosanol and omega-3 fish oil (FO) has been effective in experimental models of cerebral ischemia in rodents. This study compared the effects of policosanol and omega-3 fish oil in the global cerebral ischemia (GCI) model induced by ischemia-reperfusion in Mongolian gerbils. Gerbils were randomized distributed in seven groups: a negative control group and 6 with GCI: a positive control (vehicle), policosanol (100 and 200 mg/kg) and FO (1,25 and 2,5 g/kg) and aspirin (60 mg/kg). All treatments were administered by oral route during four weeks. Policosanol (100 and 200 mg/kg) and FO (1,25 and 2,5 g/kg) significantly reduced the clinical symptoms score (63,6 and 73,3 %; 32,7 and 58,8 %, respectively), the rate of clinical symptoms (60 y 60 %; 33,4 y 36,4 %, respectively), the hyper-locomotion (84,4 y 82,5 %; 26,7 y 100 %, respectively), the histological score of neural damage (41,4 y 52,1 %; 28,3 y 32,6 %, respectively) and the plasmatic levels of malondialdehyde (76,7 y 83,3 %; 59,9 y 72,7 %, respectively) and sulphydril groups (100 y 100 %, respectively). In conclusion, policosanol (100 and 200 mg/kg) and FO (1,25 and 2,5 g/kg) marked and significantly reduced the GCI in Mongolian gerbils, with a mayor potency and efficacy of policosanol.