Synthesis of hybrid cyclopeptides through enzymatic macrocyclization

We thank G. Mann and Dr. A. Bent, for supplying the enzymes and the useful discussions, and Dr. T. Lebl for the useful NMR discussions. This work was supported by the European Research Council (339367), UK Biotechnology and Biological Sciences Research Council (K015508/1), the Wellcome Trust (TripleTOF 5600 mass spectrometer (094476), the MALDI TOF- TOF Analyser (079272AIA), 700 NMR) and the EPSRC UK National Mass Spectrometry Facility at Swansea University. J.H.N. is a Royal Society Wolfson Merit Award Holder and 1000 talent scholar at Sichuan University. JHN, MAJ and NJW are named on patents that have been filed by St Andrews and Aberdeen University to commercialize the enzymes (PatG) and (LynD) used in the study. No income derives from the patent.