Self-reported sleep duration and daytime napping are associated with renal hyperfiltration and microalbuminuria in apparently healthy Chinese population

Background Sleep duration affects health in various way. The objective of this study was to investigate the relationship between sleep duration, daytime napping and kidney function in a middle-aged apparently healthy Chinese population. Methods According to self-reported total sleep and daytime napping duration, 33,850 participants aged 38 to 90 years old from 8 regional centers were divided into subgroups. Height, weight, waistline, hipline, blood pressure, biochemical index, FBG, PBG, HbA1c, creatinine and urinary albumin-creatinine ratio (UACR) were measured and recorded in each subject. Microalbuminuria was defined as UACR>=30 mg/g, CKD was defined as eGFR =135 ml/min. Multiple logistic regressions were applied to investigate associations between sleep and kidney function. Results Compared to participants with [7-8]h/day sleep, ORs of >9 h/day, (8, 9]h/day and =90ml/min eGFR, and N-shaped associated with sleep duration among subjects with 9h/day sleep for hyperfiltration was 1.400 (1.123-1.745, p=0.003) among eGFR>=90 ml/min participants. Daytime napping had a negative effect on renal health. Compared to participants did not have napping habit, the ORs of (0,1]h/day, (1,1.5]h/day and >1.5h/day daytime napping for microalbuminuria were 1.477 (1.370-1.591, p<0.001), 1.217 (1.056, 1.403, p=0.007) and 1.447 (1.242, 1.687, p<0.001). Conclusions Total sleep duration are U-shaped associated with renal health outcomes. Daytime napping had a negative effect on renal health.