Prevalence of complications in Multiple Sclerosis in hospitalized patient among different age groups (P1.138)

OBJECTIVE:This study is aimed to examine the prevalence of various complications according to different age groups in hospitalized MS patient during 2001 -2011. BACKGROUND: Multiple Sclerosis (MS) is a neurological disorder without any clinical findings that are unique to MS. But MS is associated with episodes of transient loss of varied CNS functions, long term complications and comorbid conditions. DESIGN/METHODS:We queried the Healthcare Cost and Utilization Project’s NIS for 2001-2011 using ICD-9-CM diagnosis code, 340 (primary or secondary diagnosis) for MS. Data for complication was extracted using ICD-9-CM diagnosis code. We used Cochran-Armitage trend test to compare age groups. The NIS is the largest all payer dataset which represents 20[percnt] of all the hospitals and all analyses were performed using the designated weighting to minimize bias. RESULTS:283,213 patients were hospitalized with MS as primary or secondary diagnosis during 2001-2011, which is national representative of 1,393,298 (weighted) patients. Prevalence of optic neuritis among MS hospitalized patients was highest (11.5[percnt]) in 0-18 age group and was declining with increasing age (p70 (p<0.001), prevalence of depression was increasing with age being highest (16.1[percnt]) in age group 50-59 and then declining with age (p70 (p<0.001). Prevalence of any types epilepsy was also increasing with age being highest (4.1[percnt]) in age group 40-49 and then decreasing with age (p<0.001). After adjusting with gender as confounder, result remains same in all age group. CONCLUSIONS:Our analysis concludes that prevalence of complications in MS hospitalized patients is highly variable in different age groups Study Supported by: Disclosure: Dr. Savani has nothing to disclose. Dr. Bhatia has nothing to disclose. Dr. Vadhavana has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Mihir has nothing to disclose. Dr. Jani has nothing to disclose.