Eremophilane sesquiterpenes and benzene derivatives from the endophyte Microdiplodia sp. WGHS5.

Three new eremophilane sesquiterpenes phomadecalins G-I ( 1 - 3 ), and two new benzene derivatives microdiplzenes A-B ( 12 and 13 ), together with nine known compounds ( 4 - 11 and 14 ) were isolated from an endophytic fungus, Microdiplodia sp. WGHS5. Their structures were elucidated by the interpretation of HRESIMS and NMR data; meanwhile, the absolute configurations of new compounds were determined on the base of ECD calculations. All compounds were evaluated for the antimicrobial activities and antiproliferative effect on human gastric cancer cell line (BGC-823).