Immediate and residual effects of low-dose nandrolone decanoate and treadmill training on adipose and reproductive tissues of male Wistar rats

AbstractContext: Residual effects after nandrolone decanoate (ND) treatment are not reported. Objective: Immediate and residual effects of low-dose ND and treadmill training were investigated. Materials and methods: Male rats were trained and/or ND-treated for four weeks and the assessments were made after this period or four weeks later. Results: The groups did not differ in final plasma glucose or AUC of the ivGTT, but hyperinsulinemia was noticed in some trained/treated groups. Training with ND increased muscle mass and ND decreased the reproductive structures. Decreased fat with training was reversed by detraining. Discussion: The anabolic action of ND on skeletal muscle was enhanced by training. Fat and lipid changes were more linked to training/detraining, but the effects of ND on the reproductive structures persisted after treatment. Conclusions: The effects of training on fat and muscle were not maintained after detraining, but low-dose ND had persistent effects on the reproductive structures.