A FT Spectral Study Of The H-Bond In Galanthamine

The hydrobromide of the alkaloid galanthamine plays an im-portant role as a medicine in curing polyomelite as well as some diseases of vegetative nervous system. Its spectral properties are investigated by means of IR /1/, UV /2/ and fluorescent spectra /3, 4/ mostly in order to determine its quantity in solutions. Information about the molecular structure of galanthamine is obtained mainly by NMR /5/ and X-ray spectroscopy /6/. In this connection an interesting, but not solved today problem is arising about the existence of H-bond in galanthamine solutions and making more clear this problem is the subject of this work. A Bruker FR-IR spectrometer with termostated cuvette and a Bomem FR-Raman spectrometer are used. The spectral region between 3400 and 3700 cm-1 is considered. The existence of an intramolecular H-bond in galanthamine molecule proved by NMR /5/ and dispersive IR spectra /7/ is confirmed here on the base of obtained FR-IR and FT-Raman spectra. An attempt is made to calculate the H-bond energy. The intermolecular H-bond forming dimers in solutions as accepted in /5/ after NMR study, but not confirmed by dispersive IR spectroscopy /7/, is investigated here by means of temperature depending spectra.