Determination of soluble Fas and ICAM-1 in the patients with acute leukemia and its correlation with chemotherapy

Objective To detect the levels of soluble Fas (sFas) and soluble ICAM-1(sICAM-1) in the patients with acute leukemia(AL) and to explore the correlation of sFas and sICAM-1 with chemotherapy.Methods The concentrations of sFas and sICAM-1 in the sera of AL patients before or after chemotherapy were detected by ELISA.Results The levels of sFas and sICAM-1 in AL patients before chemotherapy were higher that in normal controls.After chemotherapy,the levels of sFas and sICAM-1 in AL patients achieving bone marrow remission(BMR) were remarkably decreased,which were close to the levels in normal subjects.The levels of sFas and sICAM-1 in AL patients after chemotherapy achieving no BMR were similar to those before chemotherapy.The level of sFas was positively associated with that of sICAM-1 in AL patients whatever chemotherapy was given and whatever BMR was reached after chemotherapy.Conclusion The levels of sFas and sICAM-1 were increased in the patients with AL,which may be correlated with the immune escape of leukemia.The changes of level of sFas and sICAM-1 in AL patients were associated with the response to chemotherapy,which was correlated with the FasL/Fas and/or ICAM-1/LFA-1 signal transduction pathways regulated by anticancer drugs via one or more related mechanisms.