Aortic arch aneurysm in a patient with cold agglutinin disease

Cold agglutinin disease is a form of antiglobulin-positive haemolysis caused by circulating autoantibodies that are present in most humans and become active at temperatures below a threshold value [1]. Cardiac surgery requiring systemic hypothermia and cold cardioplegia carries a significant risk of agglutination of red blood cells or haemolysis in patients with cold agglutinin disease. We herein report this case to discuss treatment options with the readers.