КЛИНИЧЕСКИЕ ОСОБЕННОСТИ ТЕЧЕНИЯ ЗАБОЛЕВАНИЯ И СТРУКТУРНО-ФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ ПЕЧЕНИ У БОЛЬНЫХ НЕАЛКОГОЛЬНЫМ СТЕАТОГЕПАТИТОМ

The aim of study was to estimate the features structurally functional condition of the liver in non-alcoholic steatohepatitis patients. Methods. This case-control study involved 30 patients with non-alcoholic steatohepatitis and 10 controls aged from 18 up to 60 years. All patients and controls were examined by ultrasound of the liver with definition steatosis degree; duplex scanning of abdominal cavity vessels; elastography of the liver with definition fibrosis stage on Metavir scale. The levels of the alpha-2-macroglobulin, haptoglobin and apolipoprotein A1 were determined. Results. We revealed S 1 -steatosis degree at 60%, S 2 - at 23% and S 3 - at 17% of patients. Fibrosis of the liver was mainly initial degrees: F0 - at 10%, F1 - at 60%, F2 - at 20%, F3 - at 10% of patients. The level of alpha-2-macroglobulin was reliable increase (3,89±0,96 g/l) in the group of patients with non-alcoholic steatohepatitis in comparison with control group - 2,35±1,11 g/l (р=0,001). The obtained data have allowed to create model fibrosis liver predictors in non-alcoholic steatohepatitis patients. Conclusions. Ultrasonic steatosis degree and concentration of alpha-2-macroglobulin in combination with the body weight index and activity of hepatitis can serve the markers of the adverse forecast in non-alcoholic steatohepatitis patients.