A synonymous variant in TREX1 is associated with systemic sclerosis and severe digital ischaemia

Michael Hughes,Jayne Little,Ariane L. Herrick,Sudeep Pushpakom,Helen Byers,Jane Worthington,William G. Newman

A synonymous variant in TREX1 is associated with systemic sclerosis and severe digital ischaemia

2017

Michael Hughes
Jayne Little
Ariane L. Herrick
Sudeep Pushpakom
Helen Byers
Jane Worthington
William G. Newman

Systemic sclerosis (SSc) is characterized by progressive microvascular damage, immune system activation, and widespread fibrosis. The gene Three prime Repair EXonuclease 1 (TREX1) encodes a DNA 3ʹ ...

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Physical therapy
Ischemia
Diabetes mellitus
Surgery
Medicine
Internal medicine

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