Incidence of early-onset multiple myeloma among families with endometrial carcinoma.

1583 Background: In a recent study, multiple myeloma (MM) was found in excess and at an earlier age in first-degree relatives of endometrial carcinoma (EC) patients. We reviewed the Creighton Hereditary Cancer Center experience of MM and EC pedigrees. Methods: After identifying all probands with MM or EC we examined pedigrees with coincident diagnoses of EC and MM. The diagnosis of EC or MM was primarily verified by review of pathology reports or death certificates. Summary statistics including mean and median ages at diagnosis were calculated. Statistical analysis was used to investigate the null hypothesis of no significant age difference at diagnosis of MM and EC in families with MM, EC, and EC/MM. Results: We could not find a single individual proband with both MM and EC in our database. We found 696 individuals with EC and 126 cases of MM in 586 families. We found 26 cases of EC and 26 cases of MM in 20 families in which both cancers were reported. In contrast to the prior study, there was no signifi...