Clathrate compound of regorafenib-beta-cyclodextrin (RG-beta-CD) and preparation method thereof

The invention discloses a clathrate compound of regorafenib-beta-cyclodextrin (RG-beta-CD) and a preparation method thereof. The clathrate compound takes RG as an active pharmaceutical ingredient and beta-CD as a host molecule, wherein the molar ratio of the RG molecule to the beta-CD molecule is 1 to 1; the RG molecule and the beta-CD molecule form the clathrate compound. The clathrate compound and the preparation method have the beneficial effects that the bioavailability is greatly improved; the preparation method is simple and practicable, is mild in conditions and is suitable for industrial production; the prepared clathrate compound has wonderful pertinence to colon cancer targeted drug delivery and good safety and can effectively overcome the defects of poor water solubility and low bioavailability of RG.