GC-MS ANALYSIS AND ANTIBACTERIAL PROPERTIES OF GUM EXUDATES OF Anogeissusleiocarpus D.C
2020
This investigation was carried out to evaluate the phytochemical constituents by GC-MS analysis and determine the antibacterial properties of gum exudate of Anogeissusleiocarpus. The GC-MS analysis of the ethanolicgum extracts of A. leiocarpus was performed using a Perkin-Elmer GC clarus 500 system.The antibacterial properties of the gum exudatewas determine by disc diffusion method. The GC-MS analysis revealed the presence of various phytochemicalsin the gum extracts with the varying degree of biological activities. From the result, Fourteen (14) compounds were identified with 1H-3a-7, methanoazulene (14.31%), Alloaromadendrene(12.24%) being the most abundant compounds identified. Other compounds were, 1-4( 4-pyrimidine-2-yl) piperazin-1-yl peropane-1-one, 2,5- dimethyl-3-methylene,1,5-hexadiene, 11,-(2-cyclopentene-1-yl undecanoic acid, 1,6,10,-dodecatriene,-7,11-dimethyl-3-methylene, Bicyclo[5.1.0] octane, 8-(1-methylthyline)-, Docosa-8,14-dyn-1,2,2-diol (Z)- 2Tms derivatives, Polygalitol, Morpholine,4-methyl-4,oxide, Carbamodithioic acid, formylMethyl ester.Results of antibacterial properties showed that, the gum extracts have shown moderate activity on the test organisms. From the results, chloroform and ethanolic extract have significant activity against all the test organisms. On the effect of concentrations of the extracts, the control disc significantly recorded the highest activity in all the test organisms (P≤0.05) followed by 5000µg/disc and 3000 µg/disc of the crude extract . The activity exhibited by the extracts of the gum sample justified the use of gum exudate as a good source of modern and alternative medicine. Result of GCMS analysis will greatly be helpful for the discovery of potent remedies for various diseases.
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