Exploring dopaminergic activity in ring chromosome 20 syndrome: a SPECT study.

Aim.Several lines of evidence indicate that the dopamin-er g ic s y tm a plonh f -tic seizures and, indeed, DOPA metabolism impairmenthas recently been demonstrated in PET studies of ringch r om se20[ ( )] p a ti n. W du ylooking for correlations between r(20) mosaicism, oth-er clinical variables and both pre-synaptic dopaminetransporter (DAT) expression and post-synaptic D2receptor density.Methods.Five patients with r(20) and epilepsy wereenrolled in the study. DAT expression and D2 densitywere measured by single photon emission tomography(SPECT) imaging with 185 MBq of [