NEAR-INFRARED FLUORESCENCE (NIRF) WHOLE BODY AND INTRA-ARTERIAL MOLECULAR IMAGING OF OXIDIZED LDL IN EXPERIMENTAL ATHEROSCLEROSIS

Specific imaging of oxidized LDL in atherosclerosis could provide new approaches to detect vulnerable plaques at risk of rupture. To image oxidized LDL we generated LO1, an IgG3 monoclonal antibody against MDA-LDL, and labelled it without loss of function with a NIR fluorochrome (excitation 750nm