Recombinogenic, genotoxic, and cytotoxic effects of azathioprine using in vivo assays

A. V. D. Melo Bisneto,Laura Oliveira,A. Silva Fernandes,Leitao S. Silva,Jefferson Hollanda Véras,Clever Gomes Cardoso,Carolina Ribeiro e Silva,A.V. De Moraes Filho,Cristiene Costa Carneiro,Lee Chen Chen

Recombinogenic, genotoxic, and cytotoxic effects of azathioprine using in vivo assays

2020

A. V. D. Melo Bisneto
Laura Oliveira
A. Silva Fernandes
Leitao S. Silva
Jefferson Hollanda Véras
Clever Gomes Cardoso
Carolina Ribeiro e Silva
A.V. De Moraes Filho
Cristiene Costa Carneiro
Lee Chen Chen

Azathioprine (Aza) is a purine antimetabolite immunosuppressant that is widely employed for immunosuppressive therapy in post-transplant recipients or patients with autoimmune diseases. Chronic use...

Keywords:

Homologous recombination
Genotoxicity
Comet assay
Pharmacology
Azathioprine
In vivo
Purine Antimetabolite
Micronucleus test
Chemistry
Cytotoxic T cell

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