12-epi-fragilide G, a new briarane-type diterpenoid from the gorgonian coral Ellisella robusta

A new chlorinated briarane-type diterpenoid, 12-epi-fragilide G (1), was isolated from the gorgonian coral Ellisella robusta. The structure of 1 was elucidated by the interpretations of spectral data analysis and this compound was found to possess an s-cis diene moiety in its structure. Briarane 1 displayed inhibitory effects on elastase release by human neutrophils.