Synthesis and assay of hybrid analogs of argiotoxin-636 and philanthotoxin-433: glutamate receptor antagonists
1993
Abstract The synthesis of the non-competitive glutamate receptor antagonist, argiotoxin-636 is described. Furthermore, synthetic routes are presented for the preparation of structural analogs including argiotoxin-philanthotoxin hybrids. Biological activities on glutamate receptors are discussed.
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