Association study of LIS1 and TSNAX genes with biploar disoader in Chinese Han population

Objective To assess the association of neural development-related genes LIS1 and TSNAX with bipolar I disorder in a Chinese Han population. Methods Three hundred and eight five patients （including 188 males and 197 females） from Guangzhou Brain Hospital with bipolar I disorder meeting the Diagnostic and Statistic Manual of Bipolar I Disorder （BD-I） （Fourth Edition） criteria and 475 healthy controls from the local community were recruited. Ten single nucleotide polymorphisms （SNPs） of the LIS1 and TSNAX genes were genotyped by GoldenGate genotyping assay on an Illumina Beadstation 500 machine. Association analyses of SNPs and haplotypes were performed with Plink 1.07 software. Results Analysis of the total sample has failed to find any association of SNP or haplotype of the two genes with BD- I （P〉0.05）. When patients were divided into subgroups with or without psychotic symptom, no significant association of the two genes was found with psychotic BD-I or non-psychotic BD-I （P 〉 0. 05）. No significant association was found between any SNP or haplotype of two genes and female BD-I or male BD-I, nor were significant association found between age of onset and LIS1 and TSNAX gene polymorphisms. Conclusion Our results indicated that LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population. Key words: Bipolar I disorder;  Neural development;  LIS1 gene;  TSNAX gene