[Primary study of joint estrogenic activity of Cd2+, Pb2+, parathion and dimethoate].

OBJECTIVE: To study joint estrogenic activity of Cd2+, Pb2+, parathion and dimethoate in immature female mice. METHODS: 192 17 day-age immature female mice of ablactation were divided randomly by body weight (25g +/- 2g) into 16 groups by intraperitoneal injection at the dose of 0, 1/20LD50, 1/50LD50, 1/100LD50 Cd2+, 1/ 20LD50, 1/50LD50, 1/100LD50 Pb2+, 1/20LD50, 1/50LD50, 1/100LD50 Parathion, 1/ 20LD50, 1/50LD50, 1/100LD52 Dimethoate and 1/20LD50, 1/50LD50, 1/100LD50 Cd2+ + Pb2+ + Parathion + Dimethoat per day for 3 consecutive days. Uteruses wet weight, endometrial cells and ER were measured. RESULTS: Compared with the control group, 1/ 50LD50 Cd2+, 1/50LD50 Pb2+ and 1/100LD50 Cd2+ + Pb2+ + Parathion + Dimethoate significantly changed uteruses wet weight, 1/20LD50, 1/50LD50, 1/100LD50 Cd2+, 1/ 20LD50 Pb2+, and 1/20LD50, 1/50LD50 Cd2+ + Pb2+ + Parathion + Dimethoate significantly increased endometrial cells, all treated groups' ER were significantly increased except for 1/20LD50 and 1/50LD50 Cd2+ and 1/20LD50 Parathion. CONCLUSION: There are significant difference between singal factor and joint activity, IN joint activity, Addition effect, synergism and antagonism occurred in different treated groups and different index.