Erythrocyte Oxalate Self-Exchange Rates in Japan

Hyperoxaluria is one of the risk factors in idiopathic calcium oxalate nephrolithiasis, but detail of oxalate metabolism is still unclear. Baggio et al1 reported that the abnormal oxalate influx rate of erythrocytes suggests a defect in cellular transport of oxalate resulting in higher intestinal absorption and urinary excretion of oxalate. In order to clarify the effect of an abnormality in oxalate transport in erythrocytes in calcium oxalate nephrolithiasis, we determined erythrocyte oxalate self-exchange rates in 30 patients with recurrent calcium oxalate nephrolithiasis and 20 healthy controls.