Механизмы формирования адаптационного следа при дробном стрессировании

The analysis of neurochemical systems responses to different kinds of stress has been performed with the influences on regulatory mechanisms. It has been shown that the release of adrenal norepinephrine is enhanced by the repeated immobilization stress. The existence of noradrenergic positive feedback in myocardium is grounded which is capable to promote the ische-mic attack development. The formation of a trace at the level of hypothalamic serotoninergic system during exposition of single stress stimulus has been shown. This trace could be manifested as the hypothalamic serotoninergic system activity change with the long time delay. The role of nitric oxide system in the adaptation to cold has been discussed.