[The action mechanism of 8-azaadenine and its metal complexes with DNA].

The mechanism of the interactions of 8-azaadenine and its Co~(2+) and Cu~(2+) complexes with DNA was studied by UV and fluorescence spectra using ethidium bromide(EB) as the probe molecule.When pH 9.86,the action of 8-azaadenine-Co~(2+) with DNA was electrostatic effect and certain kind of intercalation action,when pH 7.4,the action of 8-azaadenine-Cu~(2+) with DNA was intercalation action and certain kind of electrostatic effect,when pH 2.85,the action was intercalation action and certain kind of electrostatic effect.But when pH 7.4,8-azaadenine hardly influenced the intercalation action of EB and DNA,and the action of 8-azaadenine and DNA was electrostatic action.