Does physical training increase insulin sensitivity in chronic heart failure patients

To determine the effect of training on insulin sensitivity (IS) and how this relates to peak ˙ VO2 (peak oxygen uptake) in CHF (chronic heart failure), 77 CHF patients (New York Heart Association class, II/III; men/women, 59/18; age, 60 + 9 years; body mass index, 26.7 + 3.9 kg/m 2 ; left ventricular ejection fraction, 26.9 + 8.1 %; expressed as means + S.D.) participated in the study. Patients were randomly assigned to a training or control group (TrG or CG respectively). Sixty-one patients completed the study. Patients participated in training (combined strength and endurance exercises) four times per week, two times supervised and two times at home. Before and after intervention, anthropometry, IS (euglycaemic hyperinsulinaemic clamp) and peak ˙ VO2