Highly selective catalytic cross-aldol reactions of chloral with aliphatic aldehydes
2006
An efficient synthetic method for β-trichloromethyl-β-hydroxy aldehydes is described. Using piperidine or L-prolinamide as the catalyst, direct cross-aldol reactions of chloral with aliphatic aldehydes occur smoothly at room temperature. The cross-aldol condensation products are isolated in high yields (up to 95%), and a moderate to high enantioselectivity (up to 88% ee) is observed in the case of L-prolinamide.
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