Anti-inflammatory Effect of Short Neck Clam (Tapes philippinarum) Water Extract Containing Taurine in Zebrafish Model

Short neck clam (Tapes philippinarum) water extract exhibits potent anti-inflammatory activity. However, the direct anti-inflammatory effects of short neck clam (Tapes philippinarum) in an in vivo model remained to be determined. Therefore, the present study was designed to assess the in vivo anti-inflammatory effect of short neck clam water extract containing taurine (366.83 nmol/mg) using the lipopolysaccharide (LPS)-stimulated zebrafish model. LPS-treatment significantly increased ROS and NO levels in zebrafish. However, short neck clam water extract inhibited LPS-stimulated ROS and NO generation. These results show that short neck clam water extract alleviates inflammation by inhibiting ROS and NO generation induced by LPS-treatment. In addition, short neck clam water extract protects against the toxicity induced by exposing zebrafish embryos to LPS. This outcome could explain the potential anti-inflammatory activity of short neck clam water extract containing taurine, which might have a beneficial effect during the treatment of inflammatory diseases.