Abstract 15530: Single-cell Analysis in Aortic Aneurysmal Tissue From Patients With Marfan Syndrome Reveals Increased Tgf-beta Production but Downregulation of Downstream Canonical Tgf-beta Signaling Pathways

Ashley Dawson,Yanming Li,Pingping Ren,Hernan G. Vasquez,Chen Zhang,Richard Appel,Waleed Ageedi,Wei Luo,Lin Zhang,Yang Li,Mary B. Sheppard,Hong Lu,Lisa A. Cassis,Joseph S. Coselli,Alan Daugherty,Ying H. Shen,Scott A. LeMaire

Abstract 15530: Single-cell Analysis in Aortic Aneurysmal Tissue From Patients With Marfan Syndrome Reveals Increased Tgf-beta Production but Downregulation of Downstream Canonical Tgf-beta Signaling Pathways

2020

Ashley Dawson
Yanming Li
Pingping Ren
Hernan G. Vasquez
Chen Zhang
Richard Appel
Waleed Ageedi
Wei Luo
Lin Zhang
Yang Li
Mary B. Sheppard
Hong Lu
Lisa A. Cassis
Joseph S. Coselli
Alan Daugherty
Ying H. Shen
Scott A. LeMaire

Background: Marfan syndrome (MFS) is caused by mutations in the gene for fibrillin-1 (FBN1); however, the mechanisms by which these mutations cause aortic aneurysms are poorly understood. Although ...

Keywords:

Single-cell analysis
Cancer research
downstream
Marfan syndrome
TGF-beta production
TGF beta signaling pathway
Medicine
Downregulation and upregulation

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