Platelet dysfunction in acute coronary syndromes: diagnostic aspects and relation to angiographic patency

Thrombosis on top of an atheromatus unstable plaque is now accepted as the most common mechanism underlying acute ischemic syndromes (ACS), and in that process platelet dysfunction plays a central pivotal role through interaction with the vessel wall. The present study is an attempt to highlight and re-evaluate the role of platelets in the pathogenesis of ACS via the combined approach of aggregometry and flow cytometry techniques before applying any reperfusion therapy.