Hypoxia attenuates inflammation-induced hepcidin production during experimental human endotoxaemia
2019
Hepcidin is the central mediator of iron homeostasis that limits iron availability in the extracellular compartment and causes iron-restricted erythropoiesis. Inflammation is a strong hepcidin inducer, which can lead to anemia of inflammation, whereas hypoxia can suppress hepcidin synthesis.
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