18F-Fluoride PET/CT in the detection of bone metastases in clear cell renal cell carcinoma: Discordance with bone scintigraphy

Bone metastases are a frequent complication in patients withclear cell renal cell carcinoma (RCC). Skeletal involvementfrequently shows lytic characte ristics and is related to eventssuch as pain, pathological fractures, spinal cord compressionand hypercalcaemia. Bone metastases often require palliativeradiation therapy and orthopaedic surgery [ 1, 2]. Bone scintig-raphy (BS) has long been the reference technique for thedetection of bony metastases, but is of limited value in aggres-sive osteolytic metastases andinthedetectionofearlyosteoblastic changes [3]. Instead,