Sonogashira coupling catalyzed by the Cu(Xantphos)I–Pd(OAc)2 system
2016
Abstract An efficient Pd(OAc) 2 /Cu(Xantphos)I system for Sonogashira coupling is disclosed. Aryl bromides/iodides and electron-poor aryl chlorides were suitable for this reaction. The experimental results suggest that Cu(Xantphos)I plays a unique role in which the phosphine ligand coordinates with copper.
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