Антигипоксическая активность 6-Арил-4-гидрокси-5,6-дигидро-4Н-1,3-оксазинов

The purpose of research find connections among 6-arylsubstituted-benzoilatsetil-4-hydroxy-5,6-dihydro-4H-1,3-oxazines with antihypoxic activity. Materials and Methods.Antihypoxic activity studied seven 6-aryl-substituted-4-benzoilatsetil-4-hydroxy-5,6-dihydro-4H-1,3-oxazine, obtained by reacting 1,6-diaryl-3,4-dihydroxy-2,4-hexadiene-1,6-dione with multiple Schiff bases. On two models of hypoxia hypercapnia with normobaric and hemic studied antihypoxic synthesized compounds. As a comparison drug used modern antioxidant and antihypoxant «Meksidol». Results and discussion. Assessment antihypoxic actions performed over time to increase life expectancy of mice under conditions of acute hypoxia. The synthesized compounds showed moderate and high antihypoxic activity.