Advances on human heme oxygenase-1 research

Heine oxygenase (HO) is the key enzyme in heme catabolism in mammalian cells. HO-1 is one kind of heme oxygenase isoforms, which is mainly found in liver, spleen and lung, and has the functions of regulation and protection. Present paper reviewed the structure of human HO-1 (hHO-1), the functions of hHO-1 and HO-1 inducing factors, the expression and regulation of hHO-1 gene.