Synthesis, characterization and In vitro antidiabetic activity of some substituted cyanoacetyl hydrazone derivatives

The present study describe about the synthesis, characterization and invitro antidiabetic activity of novel cyanoacetyl hydrazone derivatives. However their derivatives have been used in the fields of medicinal and pharmaceutical chemistry and reported to exhibit a variety of biological activities. The structures of all the synthesized compounds were elucidated by using spectral data. This in vitro study explores the antidiabetic properties of S1, S2 and S3 and it can be considered as a potential candidate for the management of type-II diabetes mellitus. The present findings exhibited a concentration dependent inhibition of α-amylase activity by S1, S2 and S3. The results of the study revealed that the antidiabetic activity of the S1 is much higher than that of S2 and S3 and near to the standard.