Research progress of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis

Essential of rheumatoid arthritis (RA) is destruction of invasive pannus formation in cartilage, bone and surrounding tissues Chronic inflammation of synovial membrane. Vascular endothelial growth Factor (VEGF) increases vascular permeability and induces angiogenesis. It plays a very important role in the process of joint erosion and destruction of RA. It not only promotes the formation of RA synovial pannus formation, but also acts as a direct proinflammatory factor in the pathogenesis of RA. Key words: Rheumatoid arthritis; Vascular endothelial growth factor; Synovial pannus formation; Joint erosion and destruction; Review